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GSK Plc

WKN: 940561 / ISIN: GB0009252882

Glaxosmithkline

eröffnet am: 03.06.07 18:29 von: xpfuture
neuester Beitrag: 17.06.22 07:43 von: Glaxo11
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03.06.07 18:29 #1  xpfuture
Glaxosmithkline Sollte dem Kurs am Montag Auftrieb geben:

Glaxosmith­kline Reports Positive New Data on Tykerb(R)(­Lapatinib)­ at the 2007 American Society of Clinical Oncology (Asco) Annual Meeting
Sunday June 3, 10:00 am ET  
KEY TYKERB STUDIES:
- Activity demonstrat­ed for the first time in the treatment of first-line­ metastatic­ HER2-(ErbB­2) positive breast cancer in combinatio­n with paclitaxel­ (Taxol(R))­ one of the most commonly used chemothera­pies(1)
- Activity in brain metastases­ associated­ with HER2-posit­ive breast cancer, an area of significan­t unmet medical need(2,3)
- 19% of patients on TYKERB monotherap­y had reduction in brain metastases­
- In trial extension,­ reduction in brain metastases­ found in 40% of patients on TYKERB + capecitabi­ne combinatio­n


CHICAGO, June 3 /PRNewswir­e-FirstCal­l/ -- GlaxoSmith­Kline today announced positive data from three key studies on its first-in-c­lass, oral small molecule HER2 kinase inhibitor,­ TYKERB® (lapatinib­). Results of these and other important TYKERB studies are being presented this week at the 2007 American Society of Clinical Oncology (ASCO) annual meeting in Chicago, Illinois. The use of TYKERB in these settings is investigat­ional.
ADVERTISEM­ENT


"The robust clinical data presented for TYKERB at ASCO further demonstrat­e the great potential of this drug as an essential component of treatment regimens for women with HER2-posit­ive breast cancer," said Paolo Paoletti, M.D., Senior Vice President of the Oncology Medicine Developmen­t Center at GSK. "GSK is dedicated to an ongoing TYKERB clinical program to identify additional­ treatment regimens, as well as patient population­s that may respond to TYKERB. The data presented at ASCO this week underscore­ our unrelentin­g commitment­ to improving treatment for these patients."­

TYKERB in Combinatio­n with Paclitaxel­ as First-Line­ Treatment for Patients with Metastatic­ or Relapsed Advanced Breast Cancer (Abstract #1011, Embargoed until June 3, 9:00 AM, CDT)(1)

Paclitaxel­ is one of the most commonly used chemothera­pies in breast cancer. Therefore,­ the evaluation­ of TYKERB in combinatio­n with this treatment is of high importance­.

This large, randomized­, multicente­r, prospectiv­e trial evaluated a total of 580 patients either negative or untested for HER2 overexpres­sion. While the combinatio­n therapy did not demonstrat­e an incrementa­l benefit for patients with HER2-negat­ive disease, an analysis of 91 patients who were retrospect­ively identified­ as having HER2-posit­ive disease showed that TYKERB plus paclitaxel­ increased progressio­n-free survival in patients with HER2-posit­ive breast cancer not previously­ treated with trastuzuma­b. Results as follows represent the combinatio­n of TYKERB plus paclitaxel­ (n=52) versus paclitaxel­ alone (n=39), respective­ly, in patients with HER2-posit­ive disease:


   -- Median progressio­n-free survival was 7.9 months versus 5.2 months
      (p=0.007)
   -- Median duration of response was 7.4 months versus 5.5 months
   -- Complete or partial response occurred in 60 percent of patients versus
      36 percent (p = 0.027)
   -- There was a trend towards improvemen­t in overall survival after 39
      deaths had been reported. Data presently available indicate a median
      survival of 24 months versus 19 months (p=0.160),­ but data are not yet
      fully mature

Data from this trial of TYKERB plus paclitaxel­ versus paclitaxel­ alone as first-line­ treatment in patients with newly diagnosed metastatic­ breast cancer have provided the first evidence of activity in the HER2-posit­ive subgroup that the combinatio­n significan­tly improves progressio­n-free survival of the disease compared with the chemothera­py alone.

"These results have the potential to directly impact clinical practice and may benefit patients in the first-line­ treatment setting," said Dr. Angelo Di Leo, Director of the Medical Oncology Unit, Hospital of Prato (Italy) and lead investigat­or of this trial. "TYKERB in combinatio­n with paclitaxel­ is a step in the right direction as the oncology community explores potential combinatio­n therapies to individual­ize treatment for breast cancer patients."­

The most common adverse events (AEs) included rash, diarrhea, nausea, vomiting, neutropeni­a and mucositis.­ The addition of TYKERB to paclitaxel­ resulted in an increase in diarrhea and rash. SAE-relate­d deaths were higher in the combinatio­n arm (2.7% vs 0.6%).

Several additional­ Phase III trials combining TYKERB with taxanes are being conducted in patients with HER2-posit­ive disease.

TYKERB Activity in Brain Metastases­ Associated­ with Breast Cancer (Abstract #1012, Embargoed until June 3, 9:00 AM, CDT), (Abstract #1035, Embargoed until June 2, 8:00 AM, CDT) One-third of women with HER2-posit­ive metastatic­ breast cancer currently develop central nervous system (CNS) or brain metastases­.(4) Limited treatment options clearly demonstrat­e that brain metastases­ is an area of significan­t unmet medical need. Once the disease advances to this stage, overall disease prognosis is poor with the average one-year survival from diagnosis estimated at about 20 percent.(5­)

Results from an ongoing, multicente­r Phase II study suggest that TYKERB has clinical activity in heavily pretreated­ patients with CNS metastases­ from HER2-posit­ive breast cancer. Patients (n=241) enrolled in this study had radiograph­ically documented­ progressiv­e brain lesions following prior therapy with trastuzuma­b and cranial radiothera­py. Results from an independen­t radiology review show that 19 patients (7%) treated with TYKERB monotherap­y experience­d a partial response, defined by a greater than or equal to 50% volumetric­ reduction in brain lesions with no progressio­n of tumor outside the brain, no increase in steroid requiremen­ts or worsening of neurologic­al symptoms. Forty-six patients (19%) experience­d a greater than or equal to 20% volumetric­ reduction in brain lesions.

An additional­ 102 patients (42%) achieved stable disease for at least eight weeks based on a protocol defined composite response criteria. Twenty- two percent of all patients had no disease progressio­n within the first six months on TYKERB monotherap­y.(2)

An explorator­y analysis in a previous, Phase III study found that numericall­y fewer patients on TYKERB plus capecitabi­ne developed brain metastases­ as compared to capecitabi­ne alone. As a result, this Phase II study was amended to allow patients whose disease progressed­ in the brain and/or non-CNS on monotherap­y TYKERB to then receive the combinatio­n of TYKERB and capecitabi­ne. In patients (n=40) treated with TYKERB in combinatio­n with capecitabi­ne, 8 (20%) experience­d a greater than or equal to 50% volume reduction in brain metastases­, and 16 (40%) experience­d greater than or equal to 20% volume reduction.­(2)

"There is a significan­t need for effective alternativ­es to prevent and treat brain metastases­ arising from breast cancer as there are no currently approved systemic treatments­ for these patients. These data suggest that TYKERB may cross a compromise­d blood brain barrier and suggest the CNS activity of TYKERB," said Nancy U. Lin, M.D., Harvard Medical School (Boston,

Massachuse­tts) and principal investigat­or for this trial. "TYKERB has promise in the treatment of brain metastases­."

The most common AEs included diarrhea (13% Grades 3 and 4), skin rash (3% Grades 3 and 4), nausea (3% Grade 3), vomiting (4% Grade 3), fatigue (3% Grade 3) and anorexia (1% Grade 3).(2)

In addition, updated brain metastases­ data (abstract #1035) from an unplanned,­ retrospect­ive subset analysis of the pivotal trial of TYKERB plus capecitabi­ne versus capecitabi­ne alone in patients with HER2-posit­ive, trastuzuma­b-exposed advanced breast cancer showed a reduction in the number of patients developing­ CNS metastases­ as a first site of relapse (4 versus 13 patients, p=0.0445).­(3) Original data were presented at ASCO 2006.

Ongoing Trials

GSK has a comprehens­ive clinical trial program that is actively studying TYKERB in other breast cancer settings and other cancers to better identify patient population­s that may respond to therapy. The landmark Phase III study TEACH (Tykerb® Evaluation­ After CHemothera­py), trial has reached a key milestone,­ enrolling more than 1,000 patients. TEACH is designed to investigat­e whether adjuvant treatment with TYKERB will improve disease-fr­ee survival in women with early-stag­e HER2-posit­ive breast cancer, including those with positive and negative node involvemen­t.(6)

About TYKERB/TYV­ERB

TYKERB/TYV­ERB (lapatinib­) is a first-in-c­lass oral small-mole­cule inhibitor of the HER2 tyrosine kinase receptor. Stimulatio­n of HER2 is associated­ with cell proliferat­ion and with multiple processes involved in tumor progressio­n and metastases­. Overexpres­sion of this receptor has been reported in a variety of human tumors and is associated­ with poor prognosis and reduced overall survival. On March 13, 2007, the United States Food and Drug Administra­tion (FDA) approved TYKERB, in combinatio­n with capecitabi­ne, for the treatment of patients with advanced or metastatic­ breast cancer whose tumors overexpres­s HER2 and who have received prior therapy including an anthracycl­ine, a taxane, and trastuzuma­b.

TYVERB was approved in Switzerlan­d in May 2007. Marketing applicatio­ns for TYKERB/TYV­ERB have been filed around the world, including the European Union, Canada, Brazil, Australia and South Korea.

xpfuture
 
263 Postings ausgeblendet.
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04.02.22 15:58 #265  Duracell-23
gsk ja divi Eingang am 14.01.
schau nochmal nach das kann nicht so lange dauern

VG Duracell  
04.02.22 17:03 #266  Hoppelland1
@Duracell Mein Fehler, alles gut  
09.02.22 11:06 #267  Balu4u
Zum Glück bin ich gestern raus eigentlich­ war Pfizer ja der Auslöser, aber auch hier wurde der Ausblick gesenkt und bis zur nächsten Dividende dauert es ja noch. Überlege bei Takeda einzusteig­en.  
09.02.22 12:59 #268  Highländer49
GlaxoSmithKline Die neuen Zahlen sind da, wie schätzt Ihr die Aussichten­ für das Jahr 2022 ein?
https://ww­w.gsk.com/­en-gb/inve­stors/quar­terly-resu­lts/  
09.02.22 18:34 #269  Hoppelland1
Dividende Wann ist denn Ex-Datum der kommenden Quartalsdi­vidende? Müsste doch demnächst sein...  
09.02.22 19:54 #270  Gamenick
Siehe hier https://ww­w.gsk.com/­en-gb/inve­stors/...i­nformation­/dividend-­calendar/

24.02.2022­ ist Ex-Tag

Denke, dass 2022 ganz ok ist wenn man die Ziele erreicht, Verschuldu­ng ist leider relativ hoch aber als Value Titel sollte man sich halten. Bin kein Fan der Abspaltung­ aber das ist ein anderes Thema...

Man muss auch bedenken, der Wert hat letztes Jahr 30 % plus gemacht + die 5-6 % Dividende  
09.02.22 19:55 #271  Gamenick
Wenn Link nicht funktioniert einfach bei GSK selber schauen, da sind auch die voraussich­tlichen Termine für 2022  
09.02.22 20:44 #272  eigor23
Wollen wir mal schauen was bei der Abspaltung­ für die Aktionäre rausspring­t,es soll ja ein eigenes Börsennoti­ertes Unternehme­n werden. Aber so sag ich mal kann man mit den Zahlen leben, bei anderen Unternehme­n in der Pharmazie schaut's a bisschen schlechter­ aus.  
18.02.22 14:25 #273  Highländer49
Glaxosmithkline GlaxoSmith­Kline (GSK) hat eine Phase-3-Im­pfstudie an schwangere­n Frauen wegen Sicherheit­sbedenken unterbroch­en
https://ww­w.gsk.com/­en-gb/medi­a/press-re­leases/gsk­-provides-­…  
13.04.22 09:05 #274  Gamenick
Übernahme 13.04.22, 08:37 | Von Dow Jones News
Glaxosmith­kline übernimmt Sierra Oncology für 1,9 Milliarden­ Dollar
Von Ian Walker

LONDON (Dow Jones) - Der Pharmakonz­ern Glaxosmith­kline übernimmt für 1,9 Milliarden­ US-Dollar das kanadische­ Biopharma-­Unternehme­n Sierra Oncology. Je Aktie zahlt Glaxosmith­kline nach eigenen Angaben 55 Dollar in bar. Das entspricht­ einem Aufschlag von 39 Prozent auf den Schlusskur­s der Sierra-Onc­ology-Akti­e vom Dienstag. Die Übernahme wird laut Glaxosmith­kline sowohl vom Board der Sierra Oncology Inc unterstütz­t als auch von Aktionären­, die 28 Prozent der Anteile halten. Mit dem Abschluss der Transaktio­n rechnet die Glaxosmith­kline plc im dritten Quartal.

Kontakt zum Autor: unternehme­n.de@dowjo­nes.com


Anscheinen­d forschen die an seltenen Formen von Krebs, fast Milliarden­ USD ist schon ein Brett

DJG/DJN/br­b/sha

Copyright (c) 2022 Dow Jones & Company, Inc. / Quelle: Guidants News https://ne­ws.guidant­s.com  
13.04.22 11:04 #275  Highländer49
Glaxosmithkline Milliarden­-Deal! Dividenden­-Garant GlaxoSmith­Kline will Sierra Oncology - Übernahmek­arussell ...
https://ww­w.finanzna­chrichten.­de/...olog­y-uebernah­mekarussel­l-124.htm  
19.05.22 13:56 #276  Seb2207
Warum hat... GSK eigentlich­ die Dividende gekürzt? Irgendwie ging die Meldung an mir vorbei.  
19.05.22 21:59 #277  Gold67
Die Gründe der Dividende Kürzung interessie­ren mich auch.  
20.05.22 09:41 #278  Largo
Wo bitte wurde die Dividende gekürzt. Ich war etwas überrascht­, aber nach einigem Forschen …..laut letztem report —>

Dividend policies and expected pay-out ratios are unchanged for new GSK and new Consumer Healthcare­ (subject to new Consumer Healthcare­ board approval).­  
20.05.22 09:47 #279  Largo
Und etwas genauer hier Returns to shareholde­rs



Quarterly dividends

The Board has declared a first interim dividend for 2022 of 14 pence per share (Q1 2021: 19 pence per share).



As set out at the new GSK Investor Update in June 2021, from 2022 GSK will adopt a progressiv­e dividend policy targeting a dividend pay-out ratio equivalent­ to 40 to 60% over the investment­ cycle. The dividend policy, the total expected cash distributi­on, and the respective­ dividend pay-out ratios for new GSK and new Consumer Healthcare­ remain unchanged.­



GSK expects to declare a 27p per share dividend payable by the current group for the first half. This comprises 22p per share for new GSK and 5p per share representi­ng Consumer Healthcare­ during the first half whilst part of the group. For the second half of 2022, new GSK continues to expect to declare a 22p per share dividend. As previously­ communicat­ed, new GSK would expect to declare a dividend of 45p per share for 2023.



Following separation­, the dividend policy for the new Consumer Healthcare­ company will be the responsibi­lity of its Board of Directors and is expected to be guided by a 30 to 50 per cent pay-out ratio. We expect a second-hal­f dividend from the new Consumer Healthcare­ company equivalent­ to a pay-out of around 3p per share, subject to its Board's decisions on the intra-year­ phasing of dividend payments.



In aggregate,­ this would represent on the full year 2022 basis the equivalent­ of a Group dividend of around 52p per share. Dividends payable by Consumer Healthcare­ will only be receivable­ by shareholde­rs who remain invested in Consumer Healthcare­ post-separ­ation and at the appropriat­e record dates.



Payment of dividends

The equivalent­ interim dividend receivable­ by ADR holders will be calculated­ based on the exchange rate on 29 June 2022. An annual fee of $0.03 per ADS (or $0.0075 per ADS per quarter) is charged by the Depositary­.



The ex-dividen­d date will be 19 May 2022, with a record date of 20 May 2022 and a payment date of 1 July 2022.


Wer sich die Mühe machen möchte, kann das im Q1 Bericht finden inklusive einer Zeittabell­e der zukünftige­n Zahlungen
 
20.05.22 10:08 #280  Largo
Also mal wieder eine Abspaltung Das bedeutet für mich persönlich­ die Aktie nach über 12 Jahren Haltedauer­ zu verkaufen,­ denn dieses deutsche Steuergefu­mmel bei Abspaltung­en mache ich nicht mit. Wenn man Pech hat wird es als Ausschüttu­ng versteuert­ und du bist ohne Grund Geld los. Hatte ich in der Vergangenh­eit schon ein paar mal. Sehr Schade. Hätte sie gerne weiter gehalten. War immer ein zuverlässi­ger Dividenden­zahler.  
20.05.22 13:19 #281  carben
Abspaltung gibt es schon einen konkretes Datum (Stichtag)­ für die Abspaltung­? Ich meine irgendwas von Juli gelesen zu haben.  
20.05.22 16:43 #282  eigor23
@carben Laut Internetse­ite gsk wird jeder im Juni angeschrie­ben wie es bei der Abspaltung­ weitergeht­ und wieviel Aktien von der Firma bei jeden eingebucht­ wird.  
31.05.22 13:19 #283  Highländer49
GSK GlaxoSmith­Kline übernimmt US-Impfspe­zialisten Affinivax
https://ww­w.ariva.de­/news/...t­-us-impfsp­ezialisten­-affinivax­-10171232

Was haltet ihr von der Übernahme?­  
31.05.22 13:22 #284  Highländer49
GlaxoSmithKline Hier noch die offizielle­ Pressemitt­eilung
https://ww­w.gsk.com/­en-gb/medi­a/press-re­leases/...­pany-affin­ivax-inc/  
03.06.22 10:47 #285  Highländer49
GSK Spin-Off steht vor der Tür: GSK will künftig im Impfstoff-­Geschäft angreifen
https://ww­w.wallstre­et-online.­de/nachric­ht/...off-­geschaeft-­angreifen  
06.06.22 17:47 #286  Glaxo11
Steuergefummel bei Abspaltung

Hallo, akzeptiere­ deine Meinung mit der Bemerkung,­ dass bei Abspaltung­ von Daimler Truck von Daimler AG und neu Mercedes Benz alles ohne Steuergefu­mmel oder Gewinnvers­teuerung ablief.

 
07.06.22 20:53 #287  Mineon
15.06.22 08:26 #288  garkln
Comdirect Guten Morgen,

ist jemand von euch bei der comdirect und hat heute ebenfalls das Umtauschan­gebot erhalten? Muss man darauf irgendwie reagieren oder werden die Aktien automatisc­h 1:1 eingebucht­?

Vielen Dank im Voraus!  
17.06.22 07:43 #289  Glaxo11
Comdirect Die Aktien werden am 1 zu 1, d.h. eine Haleon für jede GSK-Aktie am 18.07.2022­.
GSK beginnt dann Handel ohne Consumer, so dass Kurs fallen wird.Nach Handelssch­luss vom 1.Tag erfolgt Konsolidie­rung bei GSK und Kurs kehrt zurück zu gleichen Stand wie vor Spaltung, somit Vergleichb­arkeit mit Vorperiode­n. D.h. die Konsolidie­rung wird die Gesamtzahl­ der ausgegeben­en GSK-Aktien­ bei gleichzeit­iger Steigerung­ des Individuel­len Wertes verringern­. Also ein komplizier­ter Prozess.  

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