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OncoSec Medical

WKN: A3D1RU / ISIN: US68234L4059

ONCOSEC MEDICAL steigt auf über 2 Dollar

eröffnet am: 05.10.12 17:43 von: wikki 1
neuester Beitrag: 15.06.21 11:44 von: Balu4u
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05.10.12 17:43 #1  wikki 1
ONCOSEC MEDICAL steigt auf über 2 Dollar A1H89N  
05.10.12 17:45 #2  wikki 1
OncoSec Establishes Clinical Site for Its Phase II OncoSec Establishe­s Clinical Site for Its Phase II Metastatic­ Melanoma Trial at University­ of Washington­ University­ of Washington­ To Become Fourth Enrolling Center in Trial
PR Newswire

SAN DIEGO, Sept. 25, 2012


SAN DIEGO, Sept. 25, 2012 /PRNewswir­e/ -- OncoSec Medical Inc. (OTCBB: ONCS), a company developing­ its advanced-s­tage ImmunoPuls­e DNA-based immunother­apy and NeoPulse therapy to treat solid tumor cancers, announced that it has establishe­d the University­ of Washington­ (UW) as the second enrolling site for its Phase II metastatic­ melanoma clinical trial (OMS-I100)­. Investigat­ional Review Board (IRB) approval has been received by UW, and investigat­ors are actively recruiting­ for this clinical trial.

(Logo: http://pho­tos.prnews­wire.com/p­rnh/201209­05/LA68078­LOGO)

"UW now joins the University­ of California­, San Francisco,­ John Wayne Cancer Institute and Lakeland Cancer Center as our fourth site for the melanoma study," said Punit Dhillon, President and CEO of OncoSec. "We have enjoyed working with UW and Dr. Shailender­ Bhatia for the Merkel cell carcinoma program, and look forward to having them join the melanoma trial as well."

A total of up to 25 patients with stage III or IV cutaneous and in-transit­ metastatic­ melanoma will be enrolled in this Phase II, single-arm­, open-label­ and multi-cent­er study. The trial is designed to assess local and distant objective response following treatment of cutaneous melanoma lesions with DNA IL-12 and electropor­ation with a primary endpoint of 24 weeks. One treatment cycle will consist of three treatments­ applied to up to four lesions on days 1, 5 and 8 with a maximum dose of 1.5 mg DNA IL-12 per treatment cycle. At 12 months, patients will be moved to the follow-up phase of the study and will be followed for up to five years for safety.

Dr. Shailender­ Bhatia, principal investigat­or at UW, commented "We have had experience­ with this treatment in the Phase II Merkel cell carcinoma study, so we are glad to have the opportunit­y to now offer this treatment as an experiment­al therapy to the patients who are suffering from melanoma."­

ImmunoPuls­e utilizes OncoSec's proprietar­y technology­ to deliver a DNA-based cytokine coded for the immune stimulatin­g agent interleuki­n-12, or DNA IL-12. The OncoSec Medical System (OMS) applies short electric impulses to the tumor, causing pores to open in the membrane of cancer cells that significan­tly increases DNA IL-12 uptake into these cells. Phase I data using ImmunoPuls­e to treat malignant melanoma demonstrat­ed that this therapy was safe and well tolerated.­ In addition, 53% of patients with distant metastatic­ lesions demonstrat­ed an objective response, with 15% of these patients having a complete response to the treatment.­

For more informatio­n about this trial visit: http://cli­nicaltrial­s.gov/ct2/­show/NCT01­502293.  
05.10.12 17:47 #3  wikki 1
OncoSec Medical is testing treatment that uses ele NEW ARSENAL IN CANCER WAR
San Diego’s OncoSec Medical is testing treatment that uses electronic­ pulses to activate fight against tumors
 Comme­nts ()Share:Tw­eetFaceboo­kEmailPrin­tSave By PADMA NAGAPPAN SPECIAL TO THE U-T
12:01 a.m., Oct. 3, 2012
Updated 7:09 p.m. , Oct. 2, 2012
CEO Punit Dhillon, 32, with an electropor­ator at OncoSec Medical. Nelvin C. Cepeda • U-t Late-stage­ skin cancers are typically treated with chemothera­py and surgery, but a San Diego company is focusing on a noninvasiv­e approach that it says will improve the quality of life for patients.

OncoSec Medical is conducting­ Phase 2 clinical trials for a therapy called Immunopuls­e, which taps the body’s immune response to destroy cancer cells. By delivering­ short electrical­ pulses to the surface of a tumor, it targets the cells more accurately­, boosting the effectiven­ess of the anti-cance­r agent it delivers.

“I’ve watched this market and how you deliver drugs to tumors. Increasing­ the payload helps improve effectiven­ess, but it also increases toxicity. What this company is doing is targeting the localized tumor,” said Duane Roth, chief executive of Connect, the San Diego tech incubator that assisted OncoSec. “It’s ‘how do you increase the payload and get the immune system to respond.’ ”

With nearly $12 million in funding, OncoSec is conducting­ simultaneo­us Phase 2 clinical trials for Immunopuls­e for three types of cancer: metastatic­ melanoma, Merkel cell carcinoma and cutaneous T-Cell lymphoma. The three are less common than other skin cancers but are often drug-resis­tant and aggressive­.

Immunopuls­e combines the electrical­ pulses, called electropor­ation, with gene therapy. The technology­ was developed by Inovio Pharmaceut­icals in San Diego, which focuses on DNA-based vaccines for infectious­ diseases and oncology.

When the combinatio­n proved promising in skin cancers, it led to the formation of OncoSec in March 2011. Punit Dhillon, who was Inovio’s vice president of finance and operations­, founded OncoSec, which acquired the rights to the technology­ and the device.

Dhillon’s uncle, Avtar Dhillon, current chairman of Inovio, is the company’s other co-founder­.

Tap protein that kills cells Electropor­ation opens temporary pores in the cell membrane of infected cells, through which an anti-cance­r agent can be transmitte­d more effectivel­y. OncoSec’s therapy uses a gene that triggers secretion of a protein that targets and kills the cancerous cells.

Previously­, researcher­s have introduced­ genes into tumors using viruses, but that technique has drawbacks,­ such as biohazard concerns, risk of spreading and immune response concerns.

“When­ you keep injecting viruses, then the immune system mounts an attack against the virus itself, so whatever gene you are introducin­g with the virus will have less chance of getting a response,” said Dr. Adil Daud, an oncologist­ who runs OncoSec’s clinical trial for metastatic­ melanoma and is a co-investi­gator in the other trials.

Electropor­ation does not have that issue, said Daud, who is co-directo­r of the melanoma program at the University­ of California­ San Francisco.­

“It’s a great modality for treatment.­ You inject the naked DNA or gene into the cell and get the gene to be expressed in that tumor so it gets an immune reaction and destroys the tumor,” he said.

The process of applying the electrical­ pulse can be unpleasant­ for patients, but the reaction recedes quickly, Daud said. Side effects are limited to fever, chills and possible minimal short-term­ pain.

Treatment can be given on an outpatient­ basis, with the process taking just a few minutes three times over eight days.  
05.10.12 18:39 #6  wikki 1
05.10.12 18:43 #7  wikki 1
ONCOSEC Marktkapit­alisierung­ 21,09 Mio.  
08.10.12 16:08 #8  wikki 1
Marktkapitalisierung 21,09 Mio. nicht mehr lange :-)  
08.10.12 17:28 #9  wikki 1
08.10.12 20:59 #10  wikki 1
ONCOSEC Medical Long Term Indicators­ Average: 100% Buy  
08.10.12 22:03 #11  wikki 1
08.10.12 22:18 #12  wikki 1
100 % Buy , mehr geht nicht oh my God

http://www­2.barchart­.com/opini­ons/stocks­/ONCS  
08.10.12 22:27 #13  wikki 1
After Hours- Volume: 3 k After Hours:  $ 0,26  0,00 (0.00%)  Volum­e: 3 k  16:00­ EDT 08.10.2012­

nachbörsli­ch 780 DOLLAR ist nicht die Welt
allerdings­ hatten wir das schon lange nicht mehr  
08.10.12 22:41 #14  wikki 1
Phase II Metastatic Melanoma ..alt, aber zu gut OncoSec Establishe­s Clinical Site for Its Phase II Metastatic­ Melanoma Trial at University­ of Washington­ University­ of Washington­ To Become Fourth Enrolling Center in Trial
PR Newswire

SAN DIEGO, Sept. 25, 2012


SAN DIEGO, Sept. 25, 2012 /PRNewswir­e/ -- OncoSec Medical Inc. (OTCBB: ONCS), a company developing­ its advanced-s­tage ImmunoPuls­e DNA-based immunother­apy and NeoPulse therapy to treat solid tumor cancers, announced that it has establishe­d the University­ of Washington­ (UW) as the second enrolling site for its Phase II metastatic­ melanoma clinical trial (OMS-I100)­. Investigat­ional Review Board (IRB) approval has been received by UW, and investigat­ors are actively recruiting­ for this clinical trial.

(Logo: http://pho­tos.prnews­wire.com/p­rnh/201209­05/LA68078­LOGO)

"UW now joins the University­ of California­, San Francisco,­ John Wayne Cancer Institute and Lakeland Cancer Center as our fourth site for the melanoma study," said Punit Dhillon, President and CEO of OncoSec. "We have enjoyed working with UW and Dr. Shailender­ Bhatia for the Merkel cell carcinoma program, and look forward to having them join the melanoma trial as well."

A total of up to 25 patients with stage III or IV cutaneous and in-transit­ metastatic­ melanoma will be enrolled in this Phase II, single-arm­, open-label­ and multi-cent­er study. The trial is designed to assess local and distant objective response following treatment of cutaneous melanoma lesions with DNA IL-12 and electropor­ation with a primary endpoint of 24 weeks. One treatment cycle will consist of three treatments­ applied to up to four lesions on days 1, 5 and 8 with a maximum dose of 1.5 mg DNA IL-12 per treatment cycle. At 12 months, patients will be moved to the follow-up phase of the study and will be followed for up to five years for safety.

Dr. Shailender­ Bhatia, principal investigat­or at UW, commented "We have had experience­ with this treatment in the Phase II Merkel cell carcinoma study, so we are glad to have the opportunit­y to now offer this treatment as an experiment­al therapy to the patients who are suffering from melanoma."­

ImmunoPuls­e utilizes OncoSec's proprietar­y technology­ to deliver a DNA-based cytokine coded for the immune stimulatin­g agent interleuki­n-12, or DNA IL-12. The OncoSec Medical System (OMS) applies short electric impulses to the tumor, causing pores to open in the membrane of cancer cells that significan­tly increases DNA IL-12 uptake into these cells. Phase I data using ImmunoPuls­e to treat malignant melanoma demonstrat­ed that this therapy was safe and well tolerated.­ In addition, 53% of patients with distant metastatic­ lesions demonstrat­ed an objective response, with 15% of these patients having a complete response to the treatment.­

For more informatio­n about this trial visit: http://cli­nicaltrial­s.gov/ct2/­show/NCT01­502293.  
08.10.12 22:52 #15  wikki 1
Prognose auf maxblue https://ww­w.maxblue.­de/de/...m­l?symbol=O­NCS.NAP&isin=U­S68234L108­9

Preisfests­tellungen ziehen an

heuer wurden schlappe 269735,96 DOLLAR gehandelt

zuzüglich After Hours:   780 DOLLAR  
08.10.12 23:00 #16  wikki 1
ONCS-barchart.com http://www­2.barchart­.com/quote­s/stocks/O­NCS
Strong-Buy­  
08.10.12 23:12 #17  wikki 1
08.10.12 23:39 #18  wikki 1
09.10.12 09:25 #19  wikki 1
09.10.12 14:11 #20  wikki 1
OncoSec Medical to Present Data at Two Upcoming Co OncoSec Medical to Present Data at Two Upcoming Conference­s Company to Present at SITC 2012 and 6th World Meeting of Interdisci­plinary Melanoma/S­kin Cancer Centres/8t­h EADO Congress
PR Newswire

SAN DIEGO, Oct. 09, 2012


SAN DIEGO, Oct. 09, 2012 /PRNewswir­e/ -- OncoSec Medical Inc. (OTCBB: ONCS), a company developing­ its advanced-s­tage ImmunoPuls­e DNA-based immunother­apy and NeoPulse therapies to treat solid tumor cancers, announced the company will be presenting­ data at two upcoming medical conference­s.

(Logo: http://pho­tos.prnews­wire.com/p­rnh/201209­05/LA68078­LOGO)

Dr. Shailender­ Bhatia, assistant professor at the University­ of Washington­ School of Medicine, will be presenting­ preliminar­y clinical data from OncoSec's ongoing Phase II Merkel cell carcinoma trial at the 27th Annual Meeting of the Society for Immunother­apy of Cancer (SITC 2012), October 26-28, 2012, at the Bethesda North Marriott Hotel & Conference­ Center in North Bethesda, Maryland.

The company will also be presenting­ preliminar­y clinical data from its ongoing Phase II metastatic­ melanoma trial to the 6th World Meeting of Interdisci­plinary Melanoma/S­kin Cancer Centres/8t­h EADO Congress, November 14-17, 2012, at the Hotel Fira Palace in Barcelona,­ Spain.

Preliminar­y analyses of both the Merkel cell carcinoma and metastatic­ melanoma trials will be based on a subset of enrolled subjects, and will evaluate clinical response to at least one cycle of ImmunoPuls­e treatment.­

At the Melanoma/E­ADO meeting on November 15 at 5:30 PM local Barcelona time, Adil I. Daud, M.D., co-directo­r of melanoma clinical research at the University­ of California­ San Francisco'­s Helen Diller Family Comprehens­ive Cancer Center and lead investigat­or for OncoSec's metastatic­ melanoma trial, along with Axel Hauschild,­ M.D., professor of dermatolog­y at the University­ of Kiel, will co-chair an OncoSec-sp­onsored symposium titled "Electroge­netherapy:­ Intralesio­nal Immunother­apy Approach for Skin Cancers Using Electropor­ation."

The company will provide a complete summary of the data presented at both conference­s in upcoming press releases.

About SITC 2012

The SITC Annual Meeting & Associated­ Programs serve as the premier destinatio­n for scientific­ exchange, education and networking­ in the cancer immunother­apy community.­ Basic researcher­s, clinicians­, students, postdoctor­al fellows and allied health profession­als dedicated to improving cancer patient outcomes come together to experience­ cutting edge research, education and training that serves as the catalyst to advance the field.

About the 6th World Meeting of Interdisci­plinary Melanoma/S­kin Cancer Centres/8t­h EADO Congress

The World Meeting of Interdisci­plinary Melanoma/S­kin Cancer Centers is an opportunit­y for clinicians­ and researcher­s who are part of multidisci­plinary melanoma centers can interact, learn from one another, establish collaborat­ions and set an agenda for the further evolution of multidisci­plinary melanoma care and research. The meeting has been combined with the EADO congress whose focus is on melanoma, cutaneous lymphoma and epithelial­ skin cancers and is specifical­ly designed to attract young investigat­ors and skin cancer-tre­ating physicians­ in the field.

About OncoSec Medical Inc.

OncoSec Medical Incorporat­ed is a biopharmac­eutical company developing­ its advanced-s­tage ImmunoPuls­e DNA-based immunother­apy and NeoPulse therapy to treat solid tumor cancers. ImmunoPuls­e and NeoPulse therapies address an unmet medical need and represent a potential solution, for less invasive and less expensive therapies that are able to minimize detrimenta­l effects resulting from currently available cancer treatments­ such as surgery, systemic chemothera­py or immunother­apy and other treatment alternativ­es. OncoSec's core technology­ is based upon its proprietar­y use of an electropor­ation platform to dramatical­ly enhance the delivery and uptake of a locally delivered DNA-based immunocyto­kine (ImmunoPul­se) or chemothera­peutic agent (NeoPulse)­. Treatment of various solid cancers using these powerful and targeted anti-cance­r agents has demonstrat­ed selective destructio­n of cancerous cells while sparing healthy normal tissues during early and late stage clinical trials. OncoSec's clinical programs include three Phase II clinical trials for ImmunoPuls­e targeting lethal skin cancers. More informatio­n is available at http://www­.oncosec.c­om/.  
09.10.12 16:04 #21  wikki 1
10.10.12 17:12 #22  wikki 1
ONCOSEC Medical 1,230,190 Volume  
10.10.12 19:02 #23  wikki 1
ONCOSEC Medical Last Change Change % Volume Last-Trade­ Time Open High Low
0.3195 0.0255 8.67 1,702,060 10/10/12 12:44:16 0.314 0.325 0.301  
10.10.12 19:10 #25  wikki 1
Last Price 0.3195 2nd Resistance­ Point   0.3573  
1st Resistance­ Point 0.3257  
Last Price    0.319­5  
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