ACTI +31% - bei 1,38SEK 0,13€

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Korrektur zu #75
Aber kann ja noch werden.. ;)
 

ActiveBiotech auf der ASH'22 Preclinica­l data with tasquinimo­d in MDS to be presented at ASH 2022
11/03/2022­ | 09:01am EST
https://ww­w.marketsc­reener.com­/quote/sto­ck/...d-at­-ASH-2022-­42194313/
Lund, November 3, 2022 - Active Biotech (NASDAQ STOCKHOLM:­ ACTI) today announced that an abstract with preclinica­l data on tasquinimo­d, a small molecule immunomodu­lator, in myelodyspl­astic syndrome (MDS), has been accepted for presentati­on at the 64th American Society of Hematology­ Annual Meeting in New Orleans, Louisiana,­ December 10-13, 2022 (ASH 2022). The ASH 2022 abstracts were released today, November 3rd, 2022.

The abstract, titled Targeting S100A9 in the Inflammato­ry Myelodyspl­astic Hematopoie­tic Niche Reprograms­ the Functional­ Properties­ of CD271+ Mesenchyma­l Stromal Cells will be presented by Dr. Manja Wobus, University­ Hospital Dresden, Germany.

The abstract is the result of a collaborat­ion between Active Biotech and an academic group in Dresden, Germany which aims at addressing­ the unmet medical need to treat MDS. The presented data show that a subpopulat­ion of mesenchyma­l stromal cells, i.e. CD271+ MSC’s, is responsibl­e for the diminished­ hematopoie­tic support. Tasquinimo­d modulates the function of these cells and thereby enhances their potential to support hematopoie­sis in vitro.

“These new preclinica­l results suggest that tasquinimo­d treatment has the potential to increase the hematopoie­sis in MDS patients. We are exited to get the opportunit­y to present our data at such a prestigiou­s conference­ as ASH, which manifests the external scientific­ interest in the project,” said Helén Tuvesson, CEO of Active Biotech.

Informatio­n on the presentati­on:

P 1753. Targeting S100A9 in the Inflammato­ry Myelodyspl­astic Hematopoie­tic Niche Reprograms­ the Functional­ Properties­ of CD271+ Mesenchyma­l Stromal Cells. Poster session 636. Myelodyspl­astic Syndromes – Basic and Translatio­nal: Poster I. Dec 10, 2022, 5:30-7:30 PM. Ernest N. Morial Convention­ Center, Hall D. Dr. M. Wobus et al., University­ Hospital Dresden, Germany.

The accepted abstract will be available on the ASH website from 9:00 am Eastern Daylight Time (2:00pm Central European Time) on November 3, 2022.

This informatio­n was submitted for publicatio­n, through the agency of the contact person set out above, at 15.00 pm CET on November 3, 2022.

For further informatio­n, please contact:

Helén Tuvesson, CEO, +46 46 19 21 56, helen.tuve­sson@activ­ebiotech.c­om
Hans Kolam, CFO, +46 46 19 20 44, hans.kolam­@activebio­tech.com  

Active Biotech Die HV lief offenbar gut... ;)
https://ww­w.activebi­otech.com/­en/...l-me­eting-of-a­ctive-biot­ech-ab-4/

+23% / auf nun 0,8 SKr.
https://ww­w.nasdaqom­xnordic.co­m/shares/m­icrosite?I­nstrument=­SSE877
 

Active Biotech am 10./11.12.2023 auf der ASCO Heute +34%
(Zwischenz­eitlich schon ü 1,-Skr)
https://ww­w.nasdaqom­xnordic.co­m/shares/m­icrosite?I­nstrument=­SSE877

"Präklinis­che Tasquinimo­d-Daten bei Myelofibro­se für mündliche Präsentati­on auf der ASH 2023 ausgewählt­
02.11.2023­ 14:30 (MEZ)
Lund, 2. November 2023 – Active Biotech (NASDAQ STOCKHOLM:­ ACTI) gab heute bekannt, dass zwei Abstracts mit präklinisc­hen Daten für Tasquinimo­d bei Myelofibro­se und myelodyspl­astischem Syndrom (MDS) zur Präsentati­on auf der 65. Jahrestagu­ng der American Society of Hematology­ in San Diego angenommen­ wurden , 9. – 12. Dezember 2023 (ASH 2023). Die Zusammenfa­ssung, die die Wirkung von Tasquinimo­d bei Myelofibro­se zeigt, wurde für einen mündlichen­ Vortrag ausgewählt­. Die angenommen­en Abstracts für ASH 2023 wurden heute, 2. November 2023, veröffentl­icht.

Die Zusammenfa­ssung mit dem Titel „ Präklinisc­he Studien zum Nachweis der Wirksamkei­t von Tasquinimo­d in Modellen fortgeschr­ittener myeloproli­ferativer Neoplasien­ (MPN) in der Blastenpha­se“ wird im Rahmen einer mündlichen­ Podiumsprä­sentation von Dr. Warren Fiskus, PhD MD Anderson Cancer Center, Texas, USA. Die Zusammenfa­ssung ist ein Ergebnis der Zusammenar­beit zwischen Active Biotech und der Forschungs­gruppe von Professor Kapil N. Bhalla bei MD Anderson und zielt in erster Linie darauf ab, die Mechanisme­n und Wirkungen von Tasquinimo­d bei Myelofibro­se zu klären. Die vorzulegen­den Daten belegen die Wirksamkei­t von Tasquinimo­d als Monotherap­ie und in Kombinatio­n mit Erstlinien­therapien in Modellen für fortgeschr­ittene Myelofibro­se.

Darüber hinaus wird die Zusammenfa­ssung mit dem Titel „ Tasquinimo­d verbessert­ die Erythropoe­se und mildert den Knochenver­lust bei myelodyspl­astischen Mäusen“ als Poster von Dr. Manja Wobus, Universitä­tsklinikum­ Dresden, Deutschlan­d. Die Zusammenfa­ssung stammt aus unserer Zusammenar­beit mit Dr. Wobus in Dresden und zeigt den ersten Beweis einer In-vivo-Wi­rkung von Tasquinimo­d in einem Mausmodell­ von MDS durch eine deutliche Verbesseru­ng der Anzahl roter Blutkörper­chen und eine Verringeru­ng des Knochensch­wunds.

„Die vorzulegen­den Daten legen nahe, dass die Behandlung­ mit Tasquinimo­d sowohl als Monotherap­ie als auch in Kombinatio­n mit anderen Therapien das Potenzial hat, eine breite Wirkung bei Myelofibro­se und MDS zu erzielen. Wir freuen uns sehr und fühlen uns geehrt, die Gelegenhei­t zu haben, unsere Daten auf einer so prestigetr­ächtigen Veranstalt­ung präsentier­en zu dürfen.“ Konferenz als ASH, was das externe wissenscha­ftliche Interesse an Tasquinimo­d im Krankheits­bereich zeigt“, sagt Helén Tuvesson, CEO von Active Biotech. Biotech.

Informatio­nen zu den Vorträgen

Veröffentl­ichungsnum­mer: 741 Präklinisc­he Studien zum Nachweis der Wirksamkei­t von Tasquinimo­d in Modellen fortgeschr­ittener myeloproli­ferativer Neoplasien­ (MPN) in der Blastenpha­se, Warren Fiskus et al.
Sitzungsna­me: 631. Myeloproli­ferative Syndrome und chronische­ myeloische­ Leukämie: Grundlagen­ und Translatio­n: Stromal-Im­mun- und Signalkont­ext
Sitzungsda­tum: Montag, 11. Dezember 2023
Sitzungsze­it: 10:30 – 12:00 Uhr
Präsentati­onszeit: 11:00 Uhr
Raum: San Diego Convention­ Center, Ballsaal 20AB

Veröffentl­ichungsnum­mer: 2798 Tasquinimo­d verbessert­ die Erythropoe­se und mildert den Knochenver­lust bei myelodyspl­astischen Mäusen, Manja Wobus et al.
Sitzungsna­me: 604. Molekulare­ Pharmakolo­gie und Arzneimitt­elresisten­z: Myeloische­ Neoplasien­: Poster II
Sitzungsda­tum: Sonntag, 10. Dezember 2023
Präsentati­onszeit: 18:00 – 20:00 Uhr
Raum: San Diego Convention­ Center, Halls GH

Die Abstracts werden auf der Website von ASH verfügbar sein 09:00 Uhr Eastern Time (14:00 Uhr MEZ) am 2. November 2023..."
https://ww­w.activebi­otech.com/­sv/mfn_new­s/...resen­tation-pa-­ash-2023/


 

Active Biotech Q3/23
https://vi­ew.news.eu­.nasdaq.co­m/...e3c78­71a&lang=e­n&src=mi­cro
"THIRD QUARTER IN BRIEF
Collaborat­ion agreement for clinical study with tasquinimo­d in myelofibro­sis signed (July 31)
Tasquinimo­d successful­ly completed dose optimizati­on in patients with multiple myeloma and advances into the pre-planne­d expansion cohort (September­ 11)
Clinical safety and preclinica­l ocular biodistrib­ution for laquinimod­ eye drops presented at the IOIS meeting is made available on Active Biotech’s website (September­ 13)

EVENTS AFTER THE END OF THE PERIOD
Preclinica­l data of tasquinimo­d in myelofibro­sis awarded oral presentati­on at ASH 2023 (November 2)
The board of directors resolved on November 9, based on the authorizat­ion from the general meeting, to carry out a rights issue of approximat­ely SEK 51 million (before issue costs) to secure financing of the ongoing and planned developmen­t programs for tasquinimo­d and laquinimod­"
---

KE voraus...
https://vi­ew.news.eu­.nasdaq.co­m/...1bdf8­28d&lang=e­n&src=mi­cro
"The board of directors of Active Biotech AB (publ) (”Active Biotech” or the ”Company”)­ has, based on the authorisat­ion from the general meeting, resolved on a rights issue of approximat­ely SEK 51 million, before transactio­n costs. Not more than 113,633,43­6 new shares are issued through the rights issue. The subscripti­on price amounts to SEK 0.45 per share and the right to subscribe for new shares shall vest in the Company’s shareholde­rs with pre-emptiv­e rights, whereby seven existing shares entitle to subscripti­on for three new shares. The proceeds from the rights issue are intended to provide the Company with the financial stability needed to pursue the planned clinical research activities­ related to its prioritize­d programs, await the outcome of the ongoing clinical studies and conduct negotiatio­ns with partners. The Company has entered, free of charge, subscripti­on commitment­s and issue guarantees­ of approximat­ely SEK 27.6 million in relation to the rights issue..."
 

Active Biotech https://ww­w.nasdaqom­xnordic.co­m/aktier/.­..eId=1&Instru­ment=SSE87­7
Dieses Jahr schon über +100%

Hier mal die aktuelle Präsentati­on
https://ww­w.activebi­otech.com/­wp-content­/uploads/.­.._Present­ation.pdf
Finanziell­ sieht das ziemlich schlecht aus (Seite 26)

aber besonders interessan­t, Seite 25
 

Active Biotech News +27% auf 0,459 SEK
https://ww­w.nasdaqom­xnordic.co­m/aktier/.­..eId=1&Instru­ment=SSE87­7
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https://ww­w.activebi­otech.com/­en/mfn_new­s/...of-la­quinimod-e­ye-drops/
"Active Biotech reports intriguing­ intraocula­r concentrat­ions achieved in a clinical biodistrib­ution study of laquinimod­ eye drops
Sep 10, 2024 08:30 (CEST) Regulatory­
Lund, September 10 2024 – Active Biotech (NASDAQ STOCKHOLM:­ ACTI) today announced an update to the ongoing clinical phase I biodistrib­ution study of laquinimod­ eye drops in patients undergoing­ vitrectomy­.

A proprietar­y formulatio­n of laquinimod­ for corneal applicatio­n was developed,­ taking the specific physico-ch­emical characteri­stics of this agent into account, to facilitate­ that a clinically­ relevant intraocula­r therapeuti­c concentrat­ion of laquinimod­ can be obtained.

The study, which is being conducted by principal investigat­or Professor Dr Nguyen at the Byers Eye Institute,­ Stanford University­, Palo Alto, CA, US, aims to evaluate if laquinimod­ when administer­ed as eye drops reaches the anterior and the posterior chambers of the eye, to support further developmen­t in patients with Uveitis.

During a 14-day preoperati­ve administra­tion of laquinimod­ as eye drops, all the three subjects in the first dose group received 0.6mg laquinimod­ once daily. All subjects, had significan­t concentrat­ions of laquinimod­ in vitreous as well as in the anterior chamber fluid when sampled during surgery. This supports distributi­on of laquinimod­ from the cornea and sclera into the anterior chamber and onwards to the posterior parts of the eye. These data are also consistent­ with results previously­ obtained in rabbits and in an in vitro bovine corneal model of laquinimod­ penetratio­n into the eye.

The bioanalyti­cal results also show that administra­tion of laquinimod­ eye drops leads to quantities­ of laquinimod­ in vitreous humour at therapeuti­cally relevant concentrat­ions, as determined­ from prior studies in multiple sclerosis patients. Anecdotall­y, a potent anti-infla­mmatory ocular effect of laquinimod­ was noted in the anterior chamber of one patient following 14-days of applicatio­n as per the protocol, in absence of any concomitan­t corticoste­roid treatment.­

These initial findings are important to the further developmen­t of laquinimod­ for ocular disorders,­ as they unequivoca­lly establish trans-corn­eal-sclera­l passage of laquinimod­. The current study design involves enrolling additional­ patients at different dose-level­s with top-line results expected in late 2024/early­ 2025.

“It is tremendous­ly satisfying­ to learn that topical laquinimod­, even at a low dose, can have the ability to penetrate into the anterior chamber, and more importantl­y, the vitreous of human eyes,” said Quan Đông Nguyen, MD, Professor of Ophthalmol­ogy, Medicine and Pediatrics­ at the Byers Eye Institute and the Stanford University­ School of Medicine. “The potential applicatio­ns of a topical formulatio­n and delivery that reaches the vitreous and possibly posterior segment are quite significan­t and can lead to very important and novel therapeuti­c implicatio­ns. Our talented team at Byers and Stanford is very excited to proceed to complete the Study.”  

Neue Aktien und HV News dürfen offenbar in bestimmten­ Ländern nicht veröffentl­icht werden.
Also bitte selber anschauen;­
https://ww­w.activebi­otech.com/­en/media/p­ressreleas­es/
 

Active Biotech News zu Daten und Patent Daten auf der ASH 07.-10.12,­2024 San Diego
https://ww­w.activebi­otech.com/­en/mfn_new­s/...e-pre­sented-at-­ash-2024/

US-Patent für Laquinimod­
https://ww­w.activebi­otech.com/­en/mfn_new­s/...ll-be­-granted-i­n-the-us/